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home products Olmesartan Medoxomil Health Care Product

Olmesartan Medoxomil Health Care Product

Product Details:

Keywords Healthcare Supplies, Olmesartan Medoxomil Health Care Product, , Nutra Specialities India, India
Category Health & Medical > Health Care Products >Healthcare Supplies
Payment Terms
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Detailed Product Description


Olmesartan Medoxomil:

Olmesartan acts as an anti-hypertension agent. Olmesartan blocks the vasoconstrictor effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT 1 receptor in vascular smooth muscle. Its action is, therefore, independent of the pathways for angiotensin II synthesis. Olmesartan has more than a 12,500-fold greater affinity for the AT 1 receptor than for the AT 2 receptor.

 

Olmesartan medoxomil does not inhibit ACE (kininase II), hence it does not affect the response to bradykinin.

 

I have attached the COA and Specs for Olmesartan Medoxomil. Our Manufacturing Capacity is 1.2Mt/Month.

We are currently supplying to all major Pharma companies. Looking forward for your business cooperation. Thanks.

The patent for Olmesartan is expiring in 2016 worldwide and we are following a non-patent infringing process.

 

We are currently the biggest manufacturers of Olmesartan in India selling over 600Kgs/month. The current API pricing is above USD1500/Kg.

 

We have two grades in Olmesartan catering to different markets; we would like to know which grade you prefer.

Olmesartan Medoxomil >99%          -- USD900/Kg (Single Impurity NMT 0.5% and Total Impurity NMT 1.0%)

Olmesartan Medoxomil ICH             -- USD1330/Kg(Single Unknown Impurity NMT 0.1% and Total Impurity NMT 1.0%)

 

Looking forward for your kind feedback.

Specification 
NameOlmesartan Medoxomil
Formula

C29H30N6O6

CAS NO.[144689-63-4]
M.Wt558.59
DescriptionWhite to Yellowish colored powder
Solubility Sparingly soluble in Methanol and   insoluble in water
Identification By IR Spectra
Loss on drying (105°C-3hr)Not more than 1.0%
Heavy metalsNot more than 20 ppm
pH(2% solution in water)

4.0-7.0

Related Substances by HPLC

1. Olmesartan

Not more than 1.0%

2. Any other known impurity Not more than 0.15%
3. Any unknown impurityNot more than 0.10%
4. Total impuritiesNot more than 1.5%
5.Assay by HPLC (Dried basis)
98.0%-102%    

Residual solvents by GC

Method-I

1. MethanolNot more than 3000 ppm
2. EthanolNot more than 5000 ppm
3. Acetonitrile Not more than 4 ppm
4. AcetoneNot more than 5000 ppm
5. Isopropyl alcoholNot more than 5000 ppm
6. Methylene chlorideNot more than 600 ppm
7. Hexanes

Not more than 290 ppm

8. Ethyl acetateNot more than 5000 ppm
9. Toluene Not more than 890 ppm
Method-II
1. Acetic acidNot more than 1000 ppm  
 
  


Olmesartan Medoxomil Health Care Product

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