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home products Rafoxanide And Fenbendazole

Rafoxanide And Fenbendazole

Product Details:

Keywords Veterinary Medicine, Rafoxanide And Fenbendazole, , SPI PHARMA, India
Category Health & Medical > Animal & Veterinary >Veterinary Medicine
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Detailed Product Description


 

anthelmi nti c composi tion contai ni ng rafoxanide and fenbendazol e

This invention relates to compositions useful in the treatment and prevention of helminth infestation in non-human animals, more especially in animals of the bovine, caprine and ovine species. More particularly, the invention relates to compositions useful in the treatment of helminth infestations including fasciolides, flukes, in particular liver flukes and nematodes in bovines and ovines.

Rafoxanide (N-[3-chloro-4-(4-chlorophenoxy)-phenyl]-2- hydroxy-3,5-diiodo benzamide) is a known fasciolicide. Fenbendazole ([5(phenylthio)- l H-benzimidazol-2-yl]carbamic acid methyl ester) is a benzimidazole derivative which is known to be useful in the treatment of helminthiasis, more especially, as a nematocidal agent. Each of rafoxanide and fenbendazole is poorly soluble in many pharmaceutically acceptable solvents.

EP-A 0 202 568 describes and claims compositions containing rafoxanide and optionally various anthelmintic benzimidazoles, including fenbendazole, in association with a solvent selected from dimethyl isosorbide and glycofurol. Such compositions are indicated to overcome the problems of the art. It is stated that administration of rafoxanide with or without an anthelmintic benzimidazole derivative in a convenient dosage form, e.g., by rumen injector or oral applicator, is hindered by the extremely low solubility of each component in nearly all pharmaceutically acceptable solvents or the high viscosity of any resulting solution or suspension.

Helminth infestation is a major problem in ruminant animals, especially those on pasture. The animals must be rounded up for dosing. In the case of sheep, the animals may have to be rounded up over a wide area.

Rafoxanide and fenbendazole are both known to be taken up by the tissues, but additionally to persist in the bloodstream of ruminants and thus the amounts of rafoxanide and fenbendazole must be carefully



Rafoxanide And Fenbendazole

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